Variant position: 222 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 233 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PT-GPDPAGM-------G-----------------GTYQQPANTF DTEPQGYQSQGY
Caenorhabditis elegans ---GGDSTGI-------GHVGAPPPQSSYQSG
Baker's yeast WV-ALNTSLMPFCMKFAGKKMQKNAMQAAEAA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 233 Synaptogyrin-1
170 – 233 Cytoplasmic
194 – 233 Disordered
213 – 233 Polar residues
162 – 233 AGQAVLAFQRYQIGADSALFSQDYMDPSQDSSMPYAPYVEPTGPDPAGMGGTYQQPANTFDTEPQGYQSQGY -> SLTAALAVRRFKDLSFQEEYSTLFPASAQP. In isoform 1B and isoform 1C.
Identification of rare mutations of synaptogyrin 1 gene in patients with schizophrenia.
Cheng M.C.; Chen C.H.;
J. Psychiatr. Res. 41:1027-1031(2007)
Cited for: VARIANTS ASN-202 INS AND GLY-222;
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