Sequence information
Variant position: 326 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 392 The length of the canonical sequence.
Location on the sequence:
GLQLFVKDPALRLPTVTTVA
V PAGYDWRDIVSYVIDHFDIE
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GLQLFVKDPAL--------RLPTVTTVAV PAGYDWRDIVSYVIDHFDIE
Mouse GLKFFVKDPEI--------RLPTITTVTV PAGYNWRDIVSY
Rat GLKFFVKDPEI--------RLPTITTVTV PAGYNWRDIVSY
Rabbit GLQLFVKDPAL--------RLPTVTTVIV PASYRWRDIVSY
Cat GLQLFVKDPAL--------RLPTVTTVAV PAGYDWRDIVNY
Slime mold GLKPFV--PQLNEAPEKGGRLFSLTTVNI PDGVDGKMVMKY
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 392
Alanine--glyoxylate aminotransferase
Modified residue
312 – 312
N6-acetyllysine
Literature citations
The AGT gene in Africa: a distinctive minor allele haplotype, a polymorphism (V326I), and a novel PH1 mutation (A112D) in Black Africans.
Coulter-Mackie M.B.; Tung A.; Henderson H.E.; Toone J.R.; Applegarth D.A.;
Mol. Genet. Metab. 78:44-50(2003)
Cited for: VARIANT HP1 ASP-112; VARIANT ILE-326;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.