Variant position: 487 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 584 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GSFGGGYGGGSSGGGSSGGG HGGGHGGSSGGGYGGGS-SGGG
Mouse GSGGGSYGGSSG-GGSYGGS SGG--GGSYGGSSGGGGSYGG
Rat ------YVGNLQ-------- ------------------ITL
Bovine ------YGGGRGYGGSSGGG -----GGGYGGGSSSGG-YGG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 584 Keratin, type I cytoskeletal 10
457 – 584 Tail
17 – 575 Gly-rich
477 – 579 Ser-rich
The complete sequence of the human intermediate filament chain keratin 10. Subdomainal divisions and model for folding of end domain sequences.
Zhou X.M.; Idler W.W.; Steven A.C.; Roop D.R.; Steinert P.M.;
J. Biol. Chem. 263:15584-15589(1988)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS SER-101 AND TYR-487;
Identification of an orthologous mammalian cytokeratin gene. High degree of intron sequence conservation during evolution of human cytokeratin 10.
Rieger M.; Franke W.W.;
J. Mol. Biol. 204:841-856(1988)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT TYR-487;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANTS SER-101 AND TYR-487;
Sequence of a cDNA encoding human keratin No 10 selected according to structural homologies of keratins and their tissue-specific expression.
Darmon M.Y.; Semat A.; Darmon M.C.; Vasseur M.;
Mol. Biol. Rep. 12:277-283(1987)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 130-584; VARIANT TYR-487;
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