Variant position: 257 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 668 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LWDCPGLPGQHYCGHKEDAG AVCSEHQSWRLTGGADRCEGQ
Mouse LWDCPGRPGDQYCGHKEDAG VVCSEHQSWRLTGGIDSCEGQ
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms.
Bowen M.A.; Whitney G.S.; Neubauer M.; Starling G.C.; Palmer D.; Zhang J.; Nowak N.J.; Shows T.B.; Aruffo A.;
J. Immunol. 158:1149-1156(1997)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]; ALTERNATIVE SPLICING; VARIANT VAL-257; SUBCELLULAR LOCATION;
The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins.
Aruffo A.; Melnick M.B.; Linsley P.S.; Seed B.;
J. Exp. Med. 174:949-952(1991)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-468; VARIANT VAL-257;
Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse.
Castro M.A.; Oliveira M.I.; Nunes R.J.; Fabre S.; Barbosa R.; Peixoto A.; Brown M.H.; Parnes J.R.; Bismuth G.; Moreira A.; Rocha B.; Carmo A.M.;
J. Immunol. 178:4351-4361(2007)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-278 (ISOFORM 6); NUCLEOTIDE SEQUENCE [MRNA] OF 1-300 (ISOFORM 7); SUBCELLULAR LOCATION; VARIANTS MET-217 AND VAL-257; ALTERNATIVE SPLICING;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.