Variant position: 412 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 443 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LLSFLGRQLEAPL----PPMMASL PKKTL---LADR--------------------------SMELKNSLRLDG
Mouse LLSFLGRQLEAPV----PPVMTSL PKKTL---LANR-----
Rat LLSFLGRQLEAPL----PPVMASL PKKTL---LADR-----
Baker's yeast NFNSLRSVTKMTMYPNSPANSSVY PKTSASIALTNKLKRRR
Fission yeast GILKIRRLKRIQM--------ALY HRCNLPISLDPR-----
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
50 – 443 Magnesium transporter MRS2 homolog, mitochondrial
394 – 443 Mitochondrial matrix
118 – 443 Missing. In isoform 3.
408 – 408 M -> V. In isoform 2.
409 – 443 Missing. In isoform 2.
No reference for the current variant in UniProtKB/Swiss-Prot.
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