Variant position: 868 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1068 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human KEYPGLADPVFRTLVSQILD RAE-PLLSSSLSSEVVTVFQYY
Mouse KDYPGLAEPVFRTLVSQILD RAE-PLLSSSLSSEVITVFQY
Rat KDYPGLAEPVFRTLVSQILD RAE-PLLCSGLSSEVITVFQY
Bovine RDYPGLADPVFHTLVSQILD RAE-PLLPASLSSEVITVFQY
Chicken -------------------- ---------------------
Zebrafish QVLPHSPDSVIKMVVNEMMD RSELASSSTSPAQDVITVFQF
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1068 Rho family-interacting cell polarization regulator 2
642 – 1068 Missing. In isoform 2.
Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.
Nagase T.; Ishikawa K.; Nakajima D.; Ohira M.; Seki N.; Miyajima N.; Tanaka A.; Kotani H.; Nomura N.; Ohara O.;
DNA Res. 4:141-150(1997)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1); VARIANTS MET-320 AND GLN-868;
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