Sequence information
Variant position: 453 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 474 The length of the canonical sequence.
Location on the sequence:
PQPSPPGGSGSEPYKLLPGA
V ATIVKPLSAIPQPTITKQEV
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PQPSPPGGSGSEPYKLLPGAV ATIVKPLSAIPQPTITKQEV
Mouse PQPSPPSGSGSESYKLLPGAI TTIVKPPSAIPQPTITKQEA
Rat PQPSPPSGSGSESYKLLPGAI TTIVKPPSAIPQPTITKQEA
Xenopus laevis PQPSPPAGSGAEQYKIVHGTI ASINKQPTSIPQSTITKQEA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 474
Hepatocyte nuclear factor 4-alpha
Modified residue
436 – 436
Phosphoserine
Modified residue
458 – 458
N6-acetyllysine
Alternative sequence
378 – 474
SPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI -> PCQAQEGRGWSGDSPGDRPHTVSSPLSSLASPLCRFGQVA. In isoform HNF4-Alpha-3 and isoform HNF4-Alpha-9.
Literature citations
Submission
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ILE-139 AND ILE-453;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.