Sequence information
Variant position: 880 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1257 The length of the canonical sequence.
Location on the sequence:
TGFANKDKQELKHAGKIATE
A LENIRTIVSLTREKAFEQMY
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TGFANKDKQELKHAGKIATEA LENIRTIVSLTREKAFEQMY
Mouse AGFANRDKQALKRAGKIATEA VENIRTVVSLTRERAFEQMY
Slime mold VKYFNNDALEVER-------- -------------------Y
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 1257
ATP-binding cassette sub-family B member 5
Domain
693 – 980
ABC transmembrane type-1 2
Alternative sequence
572 – 1257
Missing. In isoform 3.
Alternative sequence
577 – 1257
Missing. In isoform 2.
Literature citations
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.
Jones S.; Zhang X.; Parsons D.W.; Lin J.C.; Leary R.J.; Angenendt P.; Mankoo P.; Carter H.; Kamiyama H.; Jimeno A.; Hong S.M.; Fu B.; Lin M.T.; Calhoun E.S.; Kamiyama M.; Walter K.; Nikolskaya T.; Nikolsky Y.; Hartigan J.; Smith D.R.; Hidalgo M.; Leach S.D.; Klein A.P.; Jaffee E.M.; Goggins M.; Maitra A.; Iacobuzio-Donahue C.; Eshleman J.R.; Kern S.E.; Hruban R.H.; Karchin R.; Papadopoulos N.; Parmigiani G.; Vogelstein B.; Velculescu V.E.; Kinzler K.W.;
Science 321:1801-1806(2008)
Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-880;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.