Sequence information
Variant position: 193 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 2458 The length of the canonical sequence.
Location on the sequence:
YSSDEDSVAGSSRESTRKGS
R ASLGALSLEAYLTTGEAETR
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human YSSDEDSVAGSSRESTRKGSR ASLGALSLEAYLTTGEAETR
Mouse NSSDEDPSAGSFQNSSRKSSR ASLGTLSQEAALNTSDPESH
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Region
174 – 193
Disordered
Modified residue
175 – 175
Phosphoserine
Modified residue
192 – 192
Phosphoserine
Modified residue
195 – 195
Phosphoserine
Modified residue
200 – 200
Phosphoserine
Modified residue
207 – 207
Phosphothreonine
Alternative sequence
1 – 202
Missing. In isoform 3.
Literature citations
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.
Jones S.; Zhang X.; Parsons D.W.; Lin J.C.; Leary R.J.; Angenendt P.; Mankoo P.; Carter H.; Kamiyama H.; Jimeno A.; Hong S.M.; Fu B.; Lin M.T.; Calhoun E.S.; Kamiyama M.; Walter K.; Nikolskaya T.; Nikolsky Y.; Hartigan J.; Smith D.R.; Hidalgo M.; Leach S.D.; Klein A.P.; Jaffee E.M.; Goggins M.; Maitra A.; Iacobuzio-Donahue C.; Eshleman J.R.; Kern S.E.; Hruban R.H.; Karchin R.; Papadopoulos N.; Parmigiani G.; Vogelstein B.; Velculescu V.E.; Kinzler K.W.;
Science 321:1801-1806(2008)
Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-193;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.