Sequence information
Variant position: 693 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 769 The length of the canonical sequence.
Location on the sequence:
NFSTCPGSGERRICSHHGVC
S NEGKCICQPDWTGKDCSIHN
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human NFSTCPGSGERRICSHHGVCS NEGKCICQPDWTGKDCSIHN
Mouse NFSTCPGSGERRICSHHGVCS NEGKCICQPDWTGKDCSIHN
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
226 – 769
Disintegrin and metalloproteinase domain-containing protein 11
Topological domain
226 – 734
Extracellular
Domain
677 – 709
EGF-like
Glycosylation
673 – 673
N-linked (GlcNAc...) asparagine
Disulfide bond
686 – 698
Alternative sequence
624 – 769
Missing. In isoform Short.
Literature citations
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.
Jones S.; Zhang X.; Parsons D.W.; Lin J.C.; Leary R.J.; Angenendt P.; Mankoo P.; Carter H.; Kamiyama H.; Jimeno A.; Hong S.M.; Fu B.; Lin M.T.; Calhoun E.S.; Kamiyama M.; Walter K.; Nikolskaya T.; Nikolsky Y.; Hartigan J.; Smith D.R.; Hidalgo M.; Leach S.D.; Klein A.P.; Jaffee E.M.; Goggins M.; Maitra A.; Iacobuzio-Donahue C.; Eshleman J.R.; Kern S.E.; Hruban R.H.; Karchin R.; Papadopoulos N.; Parmigiani G.; Vogelstein B.; Velculescu V.E.; Kinzler K.W.;
Science 321:1801-1806(2008)
Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-693;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.