Variant position: 724 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1575 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human YKQRKEYMHRRQTFIDNTDS IVKIQSWFRMATARKSYLSRL
Mouse FKQRQEYLHRQQVFAGNVDS VVKIQSWFRMVTARKSYLSRL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1575 Ras GTPase-activating-like protein IQGAP2
720 – 749 IQ 2
716 – 716 Phosphothreonine
The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases.
Brill S.; Li S.; Lyman C.W.; Church D.M.; Wasmuth J.J.; Weissbach L.; Bernards A.; Snijders A.J.;
Mol. Cell. Biol. 16:4869-4878(1996)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS GLU-527; GLU-532; PHE-629 AND VAL-724;
Cloning and characterization of a novel isoform of IQGAP2 in human adult testis.
Wang H.; Huo R.; Xu Z.Y.; Xu M.; Li J.M.; Zhou Z.M.; Sha J.H.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2); VARIANTS GLU-527; GLU-532; PHE-629 AND VAL-724;
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