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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q6ZW61: Variant p.Ile346Thr

Bardet-Biedl syndrome 12 protein
Gene: BBS12
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Variant information Variant position: help 346 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Isoleucine (I) to Threonine (T) at position 346 (I346T, p.Ile346Thr). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from medium size and hydrophobic (I) to medium size and polar (T) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help In BBS12; significantly reduces the interaction with MKKS; shows significantly decreased interaction with BBS7; the interaction with BBS10 is not affected by this mutation. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 346 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 710 The length of the canonical sequence.
Location on the sequence: help TSSCVCPGYITVVSVSNNPV I KELQNQPVRIVLIEGDLTEN The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         TSSCVCPGYITVVSVSNNPVIKELQNQPVRIVLIEGDLTEN

Mouse                         TFSRVGLGYVTFVTMSSITLIKELQDQPFRVILIEGDLTES

Xenopus laevis                EHTTVSFGYTTLVPTESAAVITHLNGKPLRILLVDGELTES

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 710 Bardet-Biedl syndrome 12 protein



Literature citations
BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly.
Seo S.; Baye L.M.; Schulz N.P.; Beck J.S.; Zhang Q.; Slusarski D.C.; Sheffield V.C.;
Proc. Natl. Acad. Sci. U.S.A. 107:1488-1493(2010)
Cited for: FUNCTION; IDENTIFICATION IN THE CHAPERONIN-CONTAINING T-COMPLEX; CHARACTERIZATION OF VARIANTS BBS12 VAL-113 DEL; LEU-159; PRO-289; THR-346; MET-501 AND VAL-540; Identification of a novel BBS gene (BBS12) highlights the major role of a vertebrate-specific branch of chaperonin-related proteins in Bardet-Biedl syndrome.
Stoetzel C.; Muller J.; Laurier V.; Davis E.E.; Zaghloul N.A.; Vicaire S.; Jacquelin C.; Plewniak F.; Leitch C.C.; Sarda P.; Hamel C.; de Ravel T.J.; Lewis R.A.; Friederich E.; Thibault C.; Danse J.-M.; Verloes A.; Bonneau D.; Katsanis N.; Poch O.; Mandel J.-L.; Dollfus H.;
Am. J. Hum. Genet. 80:1-11(2007)
Cited for: VARIANTS BBS12 VAL-113 DEL; LEU-159; PRO-289; THR-346; MET-501 AND VAL-540; VARIANTS THR-39 AND VAL-170;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.