Sequence information
Variant position: 50 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 189 The length of the canonical sequence.
Location on the sequence:
DEYDPTIEDSYRKQVVIDGE
T CLLDILDTAGQEEYSAMRDQ
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DEYDPTIEDSYRKQVVIDGET CLLDILDTAGQEEYSAMRDQ
Mouse DEYDPTIEDSYRKQVVIDGET CLLDILDTAGQEEYSAMRDQ
Rat DEYDPTIEDSYRKQVVIDGET CLLDILDTAGQEEYSAMRDQ
Pig DEYDPTIEDSYRKQVVIDGET CLLDILDTAGQEEYSAMRDQ
Chicken DEYDPTIEDSYRKQVVIDGET CLLDILDTAGQEEYSAMRDQ
Xenopus laevis DEYDPTIEDSYRKQVVIDGET CLLDILDTAGQEEYSAMRDQ
Zebrafish DEYDPTIEDSYRKQVVIDGET CLLDILDTAGQEEYSAMRDQ
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 186
GTPase NRas
Glycosylation
35 – 35
(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL
Beta strand
49 – 57
Literature citations
A restricted spectrum of NRAS mutations causes Noonan syndrome.
Cirstea I.C.; Kutsche K.; Dvorsky R.; Gremer L.; Carta C.; Horn D.; Roberts A.E.; Lepri F.; Merbitz-Zahradnik T.; Konig R.; Kratz C.P.; Pantaleoni F.; Dentici M.L.; Joshi V.A.; Kucherlapati R.S.; Mazzanti L.; Mundlos S.; Patton M.A.; Silengo M.C.; Rossi C.; Zampino G.; Digilio C.; Stuppia L.; Seemanova E.; Pennacchio L.A.; Gelb B.D.; Dallapiccola B.; Wittinghofer A.; Ahmadian M.R.; Tartaglia M.; Zenker M.;
Nat. Genet. 42:27-29(2010)
Cited for: VARIANTS NS6 ILE-50 AND GLU-60; CHARACTERIZATION OF VARIANTS NS6 ILE-50 AND GLU-60;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.