Variant position: 89 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 239 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PDPPPKDDEMETDKQEKKEV HKCGFLPGNEKVLSLLALVKP
Mouse PDPPPKDDEMETDKQEKKEV PKCGYLPGNEKLLALLALVKP
Rat PDPPPKDDEMETE-QEKKEV PKCGFLPGNEKLLALLALVKP
Pig PDPPPKDDEMETDKQEKKEV PKCGFLPGNEKILALLGLVKP
Bovine PDPPPKDDEMETDKQEKKEV PKCGFLPGNEKVLALLALVKP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 239 Proteasome activator complex subunit 2
Organization of the genes encoding the human proteasome activators PA28alpha and beta.
McCusker D.; Wilson M.; Trowsdale J.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT PRO-89;
Primary structures of two homologous subunits of PA28, a gamma-interferon-inducible protein activator of the 20S proteasome.
Ahn J.Y.; Tanahashi N.; Akiyama K.; Hisamatsu H.; Noda C.; Tanaka K.; Chung C.H.; Shibmara N.; Willy P.J.; Mott J.D.; Slaughter C.A.; DeMartino G.N.;
FEBS Lett. 366:37-42(1995)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANT PRO-89;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANT PRO-89;
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