Variant position: 274 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 329 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PVELAHLAGPGSPEAEEWGS HHGGLQEVEALSGSVHSGSVP
Mouse AVELAHLAGP---EAEEWSG HQGQ-PEVVVPSEAAHPESSS
Rat SVELAHLAGP---EAEEWSG HQGQ-PEVVVPSEAARPESSS
Bovine PVELAHLARPGSPEAEEWSG PRGGLQEVGASAGVAHARPGS
Zebrafish EALQQSSSWPNKEKKRKWGV TKEE-DDTVAPSAV-------
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 329 Protein TSSC4
265 – 265 Phosphoserine
Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting.
Lee M.P.; Brandenburg S.; Landes G.M.; Adams M.; Miller G.; Feinberg A.P.;
Hum. Mol. Genet. 8:683-690(1999)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); TISSUE SPECIFICITY; VARIANT PRO-274;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2); VARIANT PRO-274;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.