UniProtKB/SwissProt variant VAR

Keratin, type I cytoskeletal 27
Gene: KRT27
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Variant information Variant position:

52
Type of variant:

LB/B
Residue change:

From Serine (S) to Threonine (T) at position 52 (S52T, p.Ser52Thr).
Physico-chemical properties:

Change from small size and polar (S) to medium size and polar (T)
BLOSUM score:

1
Other resources:

Variant rs2469826 [ dbSNP | Ensembl ]

Sequence information Variant position:

52
Protein sequence length:

459
Location on the sequence:

AGNTCGVPGIGSGFSCAFGG S SSAGGYGGGLGGGSASCAAF
Residue conservation:

Human                         AGNTCGVPGIGSGFSCAFGGSSSAGGYGGGLGGGSASCAAF

Mouse                         AGNACGVPGIGSGFSCAFGGSSLA----GGLGMGGASCGAF

Rat                           AGNTCGVPGIGSGFSCAFGGSSLA----GGLGMGGASCGAF

Bovine                        VGSTGSVPGFGSGFTCAFGGSSSAGSYSGGLGGGSASCTAF

Goat                          VGSTGSVPGFGSGFTCAFGGSSSAGSYSGGLGGGSASCTAF

Sequence annotation in neighborhood:

Type	Positions	Description
Chain	1 – 459	Keratin, type I cytoskeletal 27
Region	1 – 83	Head

Literature citations
The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain.
Rogers M.A.; Winter H.; Langbein L.; Bleiler R.; Schweizer J.;
Differentiation 72:527-540(2004)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; TISSUE SPECIFICITY; VARIANTS THR-52; LYS-144 AND THR-305;

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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q7Z3Y8: Variant p.Ser52Thr