Variant position: 52 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 459 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human AGNTCGVPGIGSGFSCAFGG SSSAGGYGGGLGGGSASCAAF
Mouse AGNACGVPGIGSGFSCAFGG SSLA----GGLGMGGASCGAF
Rat AGNTCGVPGIGSGFSCAFGG SSLA----GGLGMGGASCGAF
Bovine VGSTGSVPGFGSGFTCAFGG SSSAGSYSGGLGGGSASCTAF
Goat VGSTGSVPGFGSGFTCAFGG SSSAGSYSGGLGGGSASCTAF
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 459 Keratin, type I cytoskeletal 27
1 – 83 Head
13 – 82 Gly-rich
The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain.
Rogers M.A.; Winter H.; Langbein L.; Bleiler R.; Schweizer J.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; TISSUE SPECIFICITY; VARIANTS THR-52; LYS-144 AND THR-305;
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