Variant position: 326 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 564 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ISSSVIITTTHCSDGSILAI ALLILFLLLALALLWWFWPLC
Mouse ISSSVIITTTHCSDGSILAI ALLVLFLLLALALLWWFWPLC
Rat ISSSVIITTTHCSDGSILAI ALLILFLLLALALLWWFWPLC
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
33 – 564 Anthrax toxin receptor 1
322 – 342 Helical
298 – 564 Missing. In isoform 3.
315 – 358 THCSDGSILAIALLILFLLLALALLWWFWPLCCTVIIKEVPPPP -> FHPSPSSPGSTSQQGTSSLPPSSKAFCLEPKVPALGSLRNFRRC. In isoform 6.
319 – 333 DGSILAIALLILFLL -> LHKIASGPTTAACME. In isoform 4.
Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma.
Jinnin M.; Medici D.; Park L.; Limaye N.; Liu Y.; Boscolo E.; Bischoff J.; Vikkula M.; Boye E.; Olsen B.R.;
Nat. Med. 14:1236-1246(2008)
Cited for: VARIANT HCI SUSCEPTIBILITY THR-326;
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