Variant position: 475 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 913 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ILKTELNNYLSINLPQRIKA HPSSIQSTFDLFFGAEELEYK
Mouse LFKGEPSRYLSINIPQ--GG KDMSIQSTLDLFFSAEELEHR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 913 Ubiquitin carboxyl-terminal hydrolase 26
295 – 886 USP
Novel mutations in testis-specific ubiquitin protease 26 gene may cause male infertility and hypogonadism.
Paduch D.A.; Mielnik A.; Schlegel P.N.;
Reprod. BioMed. Online 10:747-754(2005)
Cited for: VARIANTS PHE-364 AND TYR-475;
USP26 gene variations in fertile and infertile men.
Ribarski I.; Lehavi O.; Yogev L.; Hauser R.; Bar-Shira Maymon B.; Botchan A.; Paz G.; Yavetz H.; Kleiman S.E.;
Hum. Reprod. 24:477-484(2009)
Cited for: VARIANTS THR-123 INS; SER-165; PHE-364; TYR-475 AND ILE-579;
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