Variant position: 184 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 317 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SLELTEISRENVPKSGTPQL RLPFAARLNTPMGPGRTVVVK
Mouse ALGLTQINRENIQKPGKLQL SLPFEARLNASMGPGRTVVIK
Rat TLGLTQISKENIQKSGKLHL SLPFEARLNASMGPGRTVVVK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 317 Galectin-8
183 – 183 L -> LPSNRGGDISKIAPRTVYTKSKDSTVNHTLTCTKIPPMNYVSK. In isoform 2.
190 – 190 R -> H. Does not affect localization to cytoplasmic vesicles in case of infection by S.typhimurium.
Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen gene PCTA-1 a member of the galectin gene family.
Su Z.-Z.; Lin J.; Shen R.; Fisher P.E.; Goldstein N.I.; Fisher P.B.;
Proc. Natl. Acad. Sci. U.S.A. 93:7252-7257(1996)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS VAL-56 AND SER-184;
Molecular cloning of a beta-galactoside-binding lectin related to galectin-8 and identified in human lung carcinoma.
Brichory F.; Bidon N.; Desrues B.; Bourguet P.; Le Pennec J.-P.; Dazord L.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2); ALTERNATIVE SPLICING; VARIANTS TYR-19; CYS-36; VAL-56 AND SER-184;
Genomic organization and expression of the human galectin-8 gene.
Maier C.; Haeussler J.; Roesch K.; Moschgath E.; Vogel W.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS TYR-19; CYS-36; VAL-56 AND SER-184;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2); VARIANTS TYR-19; CYS-36; VAL-56 AND SER-184;
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