Home  |  Contact

UniProtKB/Swiss-Prot O00214: Variant p.Arg184Ser

Galectin-8
Gene: LGALS8
Variant information

Variant position:  184
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  LB/B
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Arginine (R) to Serine (S) at position 184 (R184S, p.Arg184Ser).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from large size and basic (R) to small size and polar (S)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  -1
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  184
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  317
The length of the canonical sequence.

Location on the sequence:   SLELTEISRENVPKSGTPQL  R LPFAARLNTPMGPGRTVVVK
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         SLELTEISRENVPKSGTPQLRLPFAARLNTPMGPGRTVVVK

Mouse                         ALGLTQINRENIQKPGKLQLSLPFEARLNASMGPGRTVVIK

Rat                           TLGLTQISKENIQKSGKLHLSLPFEARLNASMGPGRTVVVK

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 1 – 317 Galectin-8
Alternative sequence 183 – 183 L -> LPSNRGGDISKIAPRTVYTKSKDSTVNHTLTCTKIPPMNYVSK. In isoform 2.
Mutagenesis 190 – 190 R -> H. Does not affect localization to cytoplasmic vesicles in case of infection by S.typhimurium.


Literature citations

Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen gene PCTA-1 a member of the galectin gene family.
Su Z.-Z.; Lin J.; Shen R.; Fisher P.E.; Goldstein N.I.; Fisher P.B.;
Proc. Natl. Acad. Sci. U.S.A. 93:7252-7257(1996)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS VAL-56 AND SER-184;

Molecular cloning of a beta-galactoside-binding lectin related to galectin-8 and identified in human lung carcinoma.
Brichory F.; Bidon N.; Desrues B.; Bourguet P.; Le Pennec J.-P.; Dazord L.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2); ALTERNATIVE SPLICING; VARIANTS TYR-19; CYS-36; VAL-56 AND SER-184;

Genomic organization and expression of the human galectin-8 gene.
Maier C.; Haeussler J.; Roesch K.; Moschgath E.; Vogel W.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS TYR-19; CYS-36; VAL-56 AND SER-184;

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2); VARIANTS TYR-19; CYS-36; VAL-56 AND SER-184;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.