Variant position: 141 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 578 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DEVTLTVGSVNLEIHNGFIL GKIQLPRPKMAPANDTYESIF
Mouse DEVILTVDSVTLKAMDGIIY GTIHPPRPTITPAGDEYEQVF
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
22 – 578 Interleukin-10 receptor subunit alpha
22 – 235 Extracellular
154 – 154 N-linked (GlcNAc...) asparagine
136 – 144
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.
Glocker E.O.; Kotlarz D.; Boztug K.; Gertz E.M.; Schaffer A.A.; Noyan F.; Perro M.; Diestelhorst J.; Allroth A.; Murugan D.; Hatscher N.; Pfeifer D.; Sykora K.W.; Sauer M.; Kreipe H.; Lacher M.; Nustede R.; Woellner C.; Baumann U.; Salzer U.; Koletzko S.; Shah N.; Segal A.W.; Sauerbrey A.; Buderus S.; Snapper S.B.; Grimbacher B.; Klein C.;
N. Engl. J. Med. 361:2033-2045(2009)
Cited for: VARIANTS IBD28 ILE-84 AND ARG-141;
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