Variant position: 36 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 210 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PAP------IRRRSSN-YRAYATEPHA KKKSKISASRKLQLKTLLLQI
Mouse PAP------VRRRSSANYRAYATEPHA KKKSKISASRKLQL
Rat PAP------VRRRSSANYRAYATEPHA KKKSKISASRKLQL
Bovine PPP------VRRRSSANYRAYATEPHA KKKSKISASRKLQL
Rabbit PAP------VRRRSSANYRAYATEPHA KSKKKISASRKLQL
Cat PAP------VRRRSSANYRAYATEPHA KKKSKISASRKLQL
Horse PPP------VRRRSSANYRAYATEPHA KKKSKISASRKLQL
Xenopus laevis PPPAAPPPLIRRRSSANYRSYATEPQV KRKPKISASRKLQL
Caenorhabditis elegans KAE------VRKRMEE-----AAKKGS KKKGFLTPERKKKL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 210 Troponin I, cardiac muscle
32 – 79 Involved in binding TNC
23 – 23 Phosphoserine; by PKA and PKD/PRKD1
24 – 24 Phosphoserine; by PKA and PKD/PRKD1
26 – 26 Phosphotyrosine
31 – 31 Phosphothreonine; by STK4/MST1
42 – 42 Phosphoserine; by PKC/PRKCE
44 – 44 Phosphoserine; by PKC/PRKCE
51 – 51 Phosphothreonine; by STK4/MST1
Identification and functional characterization of cardiac troponin I as a novel disease gene in autosomal dominant dilated cardiomyopathy.
Carballo S.; Robinson P.; Otway R.; Fatkin D.; Jongbloed J.D.; de Jonge N.; Blair E.; van Tintelen J.P.; Redwood C.; Watkins H.;
Circ. Res. 105:375-382(2009)
Cited for: VARIANTS CMD1FF GLN-36 AND LYS-185;
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