Variant position: 185 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 210 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ESLDLRAHLKQVK---KEDTEKE N--REVG------DWRKN---------IDALSGMEGRK
Mouse ESLDLRAHLKQVK---KEDIEKE N--REVG------DWRKN
Rat ESLDLRAHLKQVK---KEDIEKE N--REVG------DWRKN
Bovine ETLDLRAHLKQVK---KEDTEKE N--REVG------DWRKN
Rabbit ETLDLRAHLKQVK---KEDTEKE N--REVG------DWRKN
Cat ESLDLRAHLKQVK---KEDTEKE N--REVG------DWRKN
Horse ETLDLRAHLKQVK---KEDTEKE N--REVG------DWRKN
Xenopus laevis VSMDLRANLKQVKQTKKDDADKD I--REVG------DWRKN
Caenorhabditis elegans EKSNFRNNLKVVK---KETDLDE IMAKKKGTADGKPEWSKK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Identification and functional characterization of cardiac troponin I as a novel disease gene in autosomal dominant dilated cardiomyopathy.
Carballo S.; Robinson P.; Otway R.; Fatkin D.; Jongbloed J.D.; de Jonge N.; Blair E.; van Tintelen J.P.; Redwood C.; Watkins H.;
Circ. Res. 105:375-382(2009)
Cited for: VARIANTS CMD1FF GLN-36 AND LYS-185;
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