Variant position: 30 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 758 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VMEDHAGTYGLGDRKDQGGY TMHQDQEGDTDAGLKESPLQT
Gorilla VMEDHAGTYGLGDRKDQGGY TMLQDQEGDTDAGLKESPLQT
Rhesus macaque VMEDHAGTYGLGDRKDQEGY TMLQDQEGDTDAGLKESPLQT
Chimpanzee VMEDHAGTYGLGDRKDQGGY TMHQDQEGDTDAGLKESPLQT
Mouse TMEDHA-----------GDY TLLQDQEGDMDHGLKESPPQP
Rat TMEDQA-----------GDY TMLQDQEGDMDHGLKESPPQP
Bovine VMEDHA----------QGDY T-LQDQEGDMDPGLKESPLQT
Goat VMEDHA----------QGDY T-LQDHEGDMEPGLKESPLQT
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 758 Microtubule-associated protein tau
24 – 24 Not glycated
44 – 44 Not glycated
18 – 18 Phosphotyrosine; by FYN
29 – 29 Phosphotyrosine
46 – 46 Phosphoserine
44 – 44 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
1 – 44 MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLK -> MLRALQQRKR. In isoform Tau-A.
A thorough assessment of benign genetic variability in GRN and MAPT.
Guerreiro R.J.; Washecka N.; Hardy J.; Singleton A.;
Hum. Mutat. 31:E1126-E1140(2010)
Cited for: VARIANTS MET-17; ALA-30 AND ILE-617;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.