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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot O15294: Variant p.Leu538Pro

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Gene: OGT
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Variant information Variant position: help 538
Type of variant: help US
Residue change: help From Leucine (L) to Proline (P) at position 538 (L538P, p.Leu538Pro).
Physico-chemical properties: help Similar physico-chemical property. Both residues are medium size and hydrophobic.
BLOSUM score: help -3
Variant description: help Found in a renal cell carcinoma sample; somatic mutation.


Sequence information Variant position: help 538
Protein sequence length: help 1046
Location on the sequence: help GFRKAIAERHGNLCLDKINV L HKPPYEHPKDLKLSDGRLRV
Residue conservation: help 
Human                         GFRKAIAERHGNLCLDKINV--LHKPPYEHPKDLKLSDG-RLRV

Mouse                         GFRKAIAERHGNLCLDKINV--LHKPPYEHPKDLKLSDG-R

Rat                           GFRKAIAERHGNLCLDKINV--LHKPPYEHPKDLKLSDG-R

Pig                           GFRKAIAERHGNLCLDKINV--LHKPPYEHPKDLKLSDG-R

Rabbit                        GFRKAIAERHGNLCLDKINV--LHKPPYEHPKDLKLSDG-R

Caenorhabditis elegans        AARIAIAAKHASLCFDKVHVQMLGKTPLIHADRFSVQNGQR
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 2 – 1046 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit
Helix 536 – 538



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.