Variant position: 91 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 531 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human HPVYVRRAATENIPVVRRPD RKDLLGYLNGEAST-SASIDRS
Mouse HPVYVRRAATENIPVVRRPD RKDLLGYLNGEAST-SASIDR
Rat HPVYVRRAATENIPVVRRPD RKDLLGYLNGEAST-SASIDR
Chicken HPVYVRRAATENIPVVRRPD RKDLLAYLNGETST-SSSIDR
Caenorhabditis elegans HGVYVKEAAAAGVRAVTRID RKNVTEYLQGDRTDFPALMNQ
Baker's yeast AADYLADCQNKQLTNVSFLQ RTDLINWLSGNTES-------
Fission yeast IAEYIQQCSELGIQNLTFLE RTDLISWLEGSSDS-------
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Different somatic alterations of the HRPT2 gene in a patient with recurrent sporadic primary hyperparathyroidism carrying an HRPT2 germline mutation.
Cetani F.; Pardi E.; Ambrogini E.; Viacava P.; Borsari S.; Lemmi M.; Cianferotti L.; Miccoli P.; Pinchera A.; Arnold A.; Marcocci C.;
Endocr. Relat. Cancer 14:493-499(2007)
Cited for: VARIANTS SER-2 AND PRO-91; ASSOCIATION WITH PARATHYROID ADENOMA;
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