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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P01116: Variant p.Lys5Glu

GTPase KRas
Gene: KRAS
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Variant information Variant position: help 5
Type of variant: help LP/P [Disclaimer]
Residue change: help From Lysine (K) to Glutamate (E) at position 5 (K5E, p.Lys5Glu).
Physico-chemical properties: help Change from large size and basic (K) to medium size and acidic (E)
BLOSUM score: help 1
Variant description: help In NS3.
Other resources: help


Sequence information Variant position: help 5
Protein sequence length: help 189
Location on the sequence: help MTEY K LVVVGAGGVGKSALTIQLIQ
Residue conservation: help 
Human                         MTEYKLVVVGAGGVGKSALTIQLIQ

Mouse                         MTEYKLVVVGAGGVGKSALTIQLIQ

Rat                           MTEYKLVVVGAGGVGKSALTIQLIQ

Xenopus laevis                MTEYKLVVVGAVGVGKSALTIQLIQ
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 186 GTPase KRas
Initiator methionine 1 – 1 Removed; alternate
Chain 2 – 186 GTPase KRas, N-terminally processed
Modified residue 1 – 1 N-acetylmethionine; in GTPase KRas; alternate
Modified residue 2 – 2 N-acetylthreonine; in GTPase KRas, N-terminally processed
Beta strand 3 – 9



Literature citations
Further evidence of genetic heterogeneity in Costello syndrome: involvement of the KRAS gene.
Bertola D.R.; Pereira A.C.; Brasil A.S.; Albano L.M.; Kim C.A.; Krieger J.E.;
J. Hum. Genet. 52:521-526(2007)
Cited for: VARIANT NS3 GLU-5;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.