Variant position: 602 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 931 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GIGMRLEVLGCDWTDSKPTV ETLGPTVKSEETTTPYPTEEE
Mouse GIGMRLEVLGCDWTDSKPTV ETLGPTVKSEETTTPYPMDED
Rat GIGMRLEVLGCDWTDSKPTV ETLGPTVKSEETTTPYPMDED
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
21 – 931 Neuropilin-2
21 – 864 Extracellular
556 – 931 Missing. In isoform s9.
Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III.
Chen H.; Chedotal A.; He Z.-G.; Goodman C.S.; Tessier-Lavigne M.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A0 AND A17); VARIANT LYS-602;
Genomic organization of human neuropilin-1 and neuropilin-2 genes: identification and distribution of splice variants and soluble isoforms.
Rossignol M.; Gagnon M.L.; Klagsbrun M.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS B0; B5 AND S9); VARIANT LYS-602; ALTERNATIVE SPLICING; SUBCELLULAR LOCATION;
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