Variant position: 82 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 466 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human NAFLEELRPGSLERECKEEQ CSFEEAREIFKDAERTKLFWI
Chimpanzee NAFLEELRPGSLERECKEEQ CSFEEAREIFKDLERTKLFWI
Mouse NSLLEELWPGSLERECNEEQ CSFEEAREIFKSPERTKQFWI
Rat NSLLEELWSSSLERECNEER CSFEEAREIFKSPERTKQFWT
Bovine NGFLEELLPGSLERECREEL CSFEEAHEIFRNEERTRQFWV
Rabbit NSFLEELRPGSLERECKEEL CSFEEAREVFQSTERTKQFWI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
61 – 212 Factor VII light chain
61 – 105 Gla
66 – 66 4-carboxyglutamate
67 – 67 4-carboxyglutamate
74 – 74 4-carboxyglutamate
76 – 76 4-carboxyglutamate
79 – 79 4-carboxyglutamate
80 – 80 4-carboxyglutamate
85 – 85 4-carboxyglutamate
86 – 86 4-carboxyglutamate
89 – 89 4-carboxyglutamate
95 – 95 4-carboxyglutamate
77 – 82
Factor VII deficiency: clinical manifestation of 717 subjects from Europe and Latin America with mutations in the factor 7 gene.
Herrmann F.H.; Wulff K.; Auerswald G.; Schulman S.; Astermark J.; Batorova A.; Kreuz W.; Pollmann H.; Ruiz-Saez A.; De Bosch N.; Salazar-Sanchez L.;
Cited for: VARIANTS FA7D LEU-64; GLN-73; PHE-82; PHE-84 DEL; GLY-88; PRO-88; PRO-120; CYS-128; ASP-138; GLN-139; LYS-154; SER-156; SER-157; ARG-160; PHE-171; PRO-181; ASN-183; PHE-186; SER-189; LEU-194; THR-194; ARG-195; GLN-212; ASP-216; ASN-241; THR-251; ARG-254; TYR-254; PRO-264; THR-266; ASN-272; ASN-277; TRP-283; ILE-298; GLN-301; ASN-302; HIS-302; THR-304; VAL-304; CYS-307; HIS-307; MET-312; PHE-321; LYS-325; GLN-326; CYS-337; PHE-341; SER-343; SER-345; CYS-350; VAL-354; ILE-358; PRO-360; ARG-363; HIS-363; GLN-364; TRP-364; PHE-370; TRP-375; MET-384; THR-387; VAL-387; SER-388; CYS-391; SER-391; GLU-401; HIS-403; ASN-404; GLY-413; MET-419; PHE-422; ALA-425; CYS-425; THR-429; ASP-432; GLU-435 AND PHE-437;
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