Variant position: 323 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 466 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human IALLRLHQPVVLTDHVVPLC LPERTFSERTLAFVRFSLVSG
Chimpanzee IALLRLHQPVVLTDHVVPLC LPERAFSERTLAFVRFSLVSG
Mouse IALLRLHRPVTFTDYVVPLC LPEKSFSENTLARIRFSRVSG
Rat IALVRLHRPVTFTDYVVPLC LPERAFSENTLASIRFSRVSG
Bovine VALLQLAQPVALGDHVAPLC LPDPDFADQTLAFVRFSAVSG
Rabbit IALLRLLQPAALTNNVVPLC LPERNFSESTLATIRFSRVSG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
213 – 466 Factor VII heavy chain
213 – 452 Peptidase S1
Phenotypic and genotypic characterization of Factor VII deficiency patients from Western India.
Mota L.; Shetty S.; Idicula-Thomas S.; Ghosh K.;
Clin. Chim. Acta 409:106-111(2009)
Cited for: VARIANTS FA7D ARG-82; ARG-177; THR-198; GLN-212; PRO-251; ARG-323; ARG-344; PHE-370; MET-384; GLU-398 AND ARG-408;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.