Variant position: 195 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 340 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LFNLLLQALFLIQGMFVSLF PIHLVGQLVSLLHMSLLYSLY
Mouse LFNLLLQALFLIQGMFVSLF PIHLVGQLVSLLHMSLLYSLY
Rat LFNLLLQALFLIQGMFVSLF PIHLVGQLVSLLHMSLLYSLY
Bovine LFNLLLQALFLLQGMFVSLF PIHLVGQLVSLLHMSLLYSLY
Caenorhabditis elegans LISALHQIFFLIQGMLSQYL PIPLITPVIVYLHMALLNSMY
Slime mold IYRNLLFGVILVMSAIIAFI PY---TNFINFVIITWLYSFW
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 340 Etoposide-induced protein 2.4 homolog
179 – 199 Helical
Candidate tumour suppressor genes at 11q23-q24 in breast cancer: evidence of alterations in PIG8, a gene involved in p53-induced apoptosis.
Gentile M.; Ahnstrom M.; Schon F.; Wingren S.;
Cited for: POSSIBLE INVOLVEMENT IN BREAST CANCER; VARIANTS GLY-30; TRP-195; ASP-196; TYR-197; HIS-199 AND ALA-319;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.