Variant position: 16 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 433 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MEVVDPQQLGMFTEG ELMSVGMDTFIHRIDSTE---VIY
Mouse MDVADPEPLGLFSEG ELMSVGMDTFIHRIDSTE---
Rat MDVADPQPLGLFPEG ELMSVGMDTFIHRIDSTE---
Chicken MDMQESQQLGMFGES ELMSVGMDTFIHRIDSTE---
Xenopus laevis MDEEGSEEIGFLGD- --LSVGMDTFIHRIDSTE---
Slime mold MEVEQQPSY------ ------TSNFIIHLNENEDNG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 430 Serine/threonine-protein kinase STK11
31 – 31 Phosphoserine
A novel de novo mutation in LKB1 gene in a Chinese Peutz Jeghers syndrome patient significantly diminished p53 activity.
Liu L.; Du X.; Nie J.;
Clin. Res. Hepatol. Gastroenterol. 35:221-226(2011)
Cited for: VARIANT PJS GLY-16;
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