Variant position: 835 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 993 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human RNVLVTHGKVVKICDFGLAR DIMSDSNYVVRGNARLPVKWM
Mouse RNVLVTHGKVVKICDFGLAR DILSDSSYVVRGNARLPVKWM
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
27 – 993 Receptor-type tyrosine-protein kinase FLT3
564 – 993 Cytoplasmic
610 – 943 Protein kinase
842 – 842 Phosphotyrosine; by autocatalysis
807 – 847 Missing. In isoform 2.
Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies.
Yamamoto Y.; Kiyoi H.; Nakano Y.; Suzuki R.; Kodera Y.; Miyawaki S.; Asou N.; Kuriyama K.; Yagasaki F.; Shimazaki C.; Akiyama H.; Saito K.; Nishimura M.; Motoji T.; Shinagawa K.; Takeshita A.; Saito H.; Ueda R.; Ohno R.; Naoe T.;
Cited for: VARIANTS ASN-835; GLU-835; HIS-835; VAL-835 AND TYR-835; CHARACTERIZATION OF VARIANTS ASN-835; GLU-835; HIS-835; VAL-835 AND TYR-835; PHOSPHORYLATION; INVOLVEMENT IN AML;
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