Variant position: 836 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 993 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human NVLVTHGKVVKICDFGLARD IMSDSNYVVRGNARLPVKWMA
Mouse NVLVTHGKVVKICDFGLARD ILSDSSYVVRGNARLPVKWMA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
27 – 993 Receptor-type tyrosine-protein kinase FLT3
564 – 993 Cytoplasmic
610 – 943 Protein kinase
842 – 842 Phosphotyrosine; by autocatalysis
807 – 847 Missing. In isoform 2.
836 – 838
FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy.
Taketani T.; Taki T.; Sugita K.; Furuichi Y.; Ishii E.; Hanada R.; Tsuchida M.; Sugita K.; Ida K.; Hayashi Y.;
Cited for: VARIANTS GLU-835; HIS-835; TYR-835; ILE-836 DEL AND MET-836; FUNCTION IN ACTIVATION OF STAT5A AND/OR STAT5B; PHOSPHORYLATION; INVOLVEMENT IN AML;
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