Variant position: 188 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 459 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SLYYFNYLDSTAYPPSELLS GHLFPSGLLNAQAPAALAAHP
Mouse SLYYFNYLDSTAYPPSELLG GHLFPSGLLNAQAPTSLAAHP
Bovine SLYYFNYLDSATYPSSELLG GHLFPSGLLNTQAPAALAAHP
Xenopus laevis SFYYFNYLESSFHPP-DLLN GQLLSSSLINAQSQATLSAHH
Xenopus tropicalis SLYYFNYLDSSFHPP-EILS GQLLSSSLINAQSQATLSAQQ
Zebrafish SLCYFNYLDSAYQS--ELLS GHLFSSAIANSQAQA-ISAHQ
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 459 Fez family zinc finger protein 2
Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis.
Daoud H.; Valdmanis P.N.; Gros-Louis F.; Belzil V.; Spiegelman D.; Henrion E.; Diallo O.; Desjarlais A.; Gauthier J.; Camu W.; Dion P.A.; Rouleau G.A.;
Arch. Neurol. 68:587-593(2011)
Cited for: VARIANT ASP-188;
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