Variant position: 647 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 979 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DNPHVLVDTLTSHSFTLSWK DYSTESQPGFIQGYHVYLKSK
Mouse VNPKVEIPYSTPNSFVLRWP DYDSDFQAGFIKGYLVYVKSK
Rat VNPGVTIHNLTPNSFSLKWQ DYASDFQSGFIKGYLVYLKSK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
28 – 979 Oncostatin-M-specific receptor subunit beta
28 – 740 Extracellular
625 – 736 Fibronectin type-III 4
343 – 979 Missing. In isoform 2.
Novel IL31RA gene mutation and ancestral OSMR mutant allele in familial primary cutaneous amyloidosis.
Lin M.W.; Lee D.D.; Liu T.T.; Lin Y.F.; Chen S.Y.; Huang C.C.; Weng H.Y.; Liu Y.F.; Tanaka A.; Arita K.; Lai-Cheong J.; Palisson F.; Chang Y.T.; Wong C.K.; Matsuura I.; McGrath J.A.; Tsai S.F.;
Eur. J. Hum. Genet. 18:26-32(2010)
Cited for: VARIANTS PLCA1 VAL-647; LEU-694 AND THR-697;
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