Variant position: 37 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 235 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human CNLLCLPENYQMKYYFYHGL SWPQLSYIAEDENGKIVGYVL
Mouse CNLLCLPENYQMKYYFYHGL SWPQLSYIAEDENGKIVGYVL
Bovine CNLLCLPENYQMKYYFYHGL SWPQLSYIAEDENGKIVGYVL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 235 N-alpha-acetyltransferase 10
1 – 152 N-acetyltransferase
1 – 58 Interaction with NAA15
Using VAAST to identify an X-linked disorder resulting in lethality in male infants due to N-terminal acetyltransferase deficiency.
Rope A.F.; Wang K.; Evjenth R.; Xing J.; Johnston J.J.; Swensen J.J.; Johnson W.E.; Moore B.; Huff C.D.; Bird L.M.; Carey J.C.; Opitz J.M.; Stevens C.A.; Jiang T.; Schank C.; Fain H.D.; Robison R.; Dalley B.; Chin S.; South S.T.; Pysher T.J.; Jorde L.B.; Hakonarson H.; Lillehaug J.R.; Biesecker L.G.; Yandell M.; Arnesen T.; Lyon G.J.;
Am. J. Hum. Genet. 89:28-43(2011)
Cited for: VARIANT NATD PRO-37; CHARACTERIZATION OF VARIANT NATD PRO-37;
Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects.
Myklebust L.M.; Van Damme P.; Stoeve S.I.; Doerfel M.J.; Abboud A.; Kalvik T.V.; Grauffel C.; Jonckheere V.; Wu Y.; Swensen J.; Kaasa H.; Liszczak G.; Marmorstein R.; Reuter N.; Lyon G.J.; Gevaert K.; Arnesen T.;
Hum. Mol. Genet. 24:1956-1976(2015)
Cited for: VARIANT NATD PRO-37; CHARACTERIZATION OF VARIANT NATD PRO-37; FUNCTION; CATALYTIC ACTIVITY; SUBCELLULAR LOCATION;
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