Variant position: 270 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1401 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GWMHHTVDLLGDKATKESYA IQYLQKSLEADPNSGQSWYFL
Mouse GWMHHTVDLLGDKATKESYA IQYLQKSLEADPNSGQSWYFL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1401 Lysine-specific demethylase 6A
250 – 283 TPR 5
1 – 1095 Interaction with SUPT6H
Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A.
Jankowska A.M.; Makishima H.; Tiu R.V.; Szpurka H.; Huang Y.; Traina F.; Visconte V.; Sugimoto Y.; Prince C.; O'Keefe C.; Hsi E.D.; List A.; Sekeres M.A.; Rao A.; McDevitt M.A.; Maciejewski J.P.;
Cited for: VARIANTS VAL-270; ASP-834 AND LYS-922;
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