Sequence information
Variant position: 766 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 972 The length of the canonical sequence.
Location on the sequence:
DGRPLELRDLLHFSSQVAQG
M AFLASKNCIHRDVAARNVLL
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DGRPLELRDLLHFSSQVAQGM AFLASKNCIHRDVAARNVLL
Mouse ASRPLELWDLLHFSSQVAQGM AFLASKNCIHRDVAARNVLL
Rat PSRPLELWDLLHFSSQVAQGM AFLASKNCIHRDVAARNVLL
Cat DGRPLELRDLLHFSSQVAQGM AFLASKNCIHRDVAARNVLL
Zebrafish DSWPLDMDDLLRFSSQVAQGL DFLAAKNCIHRDVAARNVLL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
20 – 972
Macrophage colony-stimulating factor 1 receptor
Topological domain
539 – 972
Cytoplasmic
Domain
582 – 910
Protein kinase
Active site
778 – 778
Proton acceptor
Alternative sequence
307 – 972
Missing. In isoform 2.
Helix
752 – 771
Literature citations
Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids.
Rademakers R.; Baker M.; Nicholson A.M.; Rutherford N.J.; Finch N.; Soto-Ortolaza A.; Lash J.; Wider C.; Wojtas A.; DeJesus-Hernandez M.; Adamson J.; Kouri N.; Sundal C.; Shuster E.A.; Aasly J.; MacKenzie J.; Roeber S.; Kretzschmar H.A.; Boeve B.F.; Knopman D.S.; Petersen R.C.; Cairns N.J.; Ghetti B.; Spina S.; Garbern J.; Tselis A.C.; Uitti R.; Das P.; Van Gerpen J.A.; Meschia J.F.; Levy S.; Broderick D.F.; Graff-Radford N.; Ross O.A.; Miller B.B.; Swerdlow R.H.; Dickson D.W.; Wszolek Z.K.;
Nat. Genet. 44:200-205(2012)
Cited for: VARIANTS HDLS 774-CYS--ASN-814 DEL; 585-GLY--LYS-619 DELINS ALA; GLU-589; LYS-633; THR-766; PRO-770; ASN-775; THR-794; TYR-837; SER-849; PHE-849 DEL; PRO-868; THR-875 AND THR-878; VARIANTS HIS-710; ARG-747 AND ASP-920; CHARACTERIZATION OF VARIANTS HDLS LYS-633; THR-766 AND THR-875;
CSF1R mutations link POLD and HDLS as a single disease entity.
Nicholson A.M.; Baker M.C.; Finch N.A.; Rutherford N.J.; Wider C.; Graff-Radford N.R.; Nelson P.T.; Clark H.B.; Wszolek Z.K.; Dickson D.W.; Knopman D.S.; Rademakers R.;
Neurology 80:1033-1040(2013)
Cited for: VARIANTS HDLS THR-766 AND HIS-782; CHARACTERIZATION OF VARIANTS HDLS HIS-782 AND THR-875; AUTOPHOSPHORYLATION;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.