UniProtKB/SwissProt variant VAR

Variant information

Variant position:

167

The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:

LB/B

The variants are classified into three categories: LP/P, LB/B and US.

LP/P: likely pathogenic or pathogenic.
LB/B: likely benign or benign.
US: uncertain significance

Residue change:

From Lysine (K) to Methionine (M) at position 167 (K167M, p.Lys167Met).

Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:

Change from large size and basic (K) to medium size and hydrophobic (M)

The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:

-1

The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:

Lowest score: -4 (low probability of substitution).
Highest score: 11 (high probability of substitution).

More information can be found on the following page

Sequence information

Variant position:

167

The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:

279

The length of the canonical sequence.

Location on the sequence:

QNFCVPCYEKQHAMQCVQCK K PITTGGVTYREQPWHKECFV

The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation:

The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         QNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQPWHKECFV

Mouse                         QNFCVPCYEKQYALQCVQCKKPITTGGVTYREQPWHKECFV

Rat                           QNFCVPCYEKQYALQCVQCKKPITTGGVTYRDQPWHRECFV

Bovine                        ENFCVPCYERQYALQCVQCKKPITTGGVTYREQPWHRECFV

Sequence annotation in neighborhood:

The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:

Type: the type of sequence feature.
Positions: endpoints of the sequence feature.
Description: contains additional information about the feature.

Type	Positions	Description
Chain	1 – 279	Four and a half LIM domains protein 2
Domain	162 – 212	LIM zinc-binding 3
Cross	167 – 167	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Alternative sequence	152 – 279	Missing. In isoform 2.

Literature citations

Molecular cloning and characterization of FHL2, a novel LIM domain protein preferentially expressed in human heart.
Chan K.K.; Tsui S.K.W.; Lee S.M.Y.; Luk S.C.W.; Liew C.C.; Fung K.P.; Waye M.M.Y.; Lee C.Y.;
Gene 210:345-350(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT MET-167;

The FHL2 LIM-domain protein is implicated in hematopoiesis and leukemogenesis.
Qian Z.; Mao L.; Fernald A.; Yu H.; Luo R.; Anastasi J.; Le Beau M.M.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT MET-167;

Slim defines a novel family of LIM-proteins expressed in skeletal muscle.
Morgan M.J.; Madgwick A.J.A.;
Biochem. Biophys. Res. Commun. 225:632-638(1996)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 127-279 (ISOFORM 1); VARIANT MET-167;

UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q14192: Variant p.Lys167Met