Sequence information
Variant position: 167 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 279 The length of the canonical sequence.
Location on the sequence:
QNFCVPCYEKQHAMQCVQCK
K PITTGGVTYREQPWHKECFV
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human QNFCVPCYEKQHAMQCVQCKK PITTGGVTYREQPWHKECFV
Mouse QNFCVPCYEKQYALQCVQCKK PITTGGVTYREQPWHKECFV
Rat QNFCVPCYEKQYALQCVQCKK PITTGGVTYRDQPWHRECFV
Bovine ENFCVPCYERQYALQCVQCKK PITTGGVTYREQPWHRECFV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 279
Four and a half LIM domains protein 2
Domain
162 – 212
LIM zinc-binding 3
Cross
167 – 167
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Alternative sequence
152 – 279
Missing. In isoform 2.
Literature citations
Molecular cloning and characterization of FHL2, a novel LIM domain protein preferentially expressed in human heart.
Chan K.K.; Tsui S.K.W.; Lee S.M.Y.; Luk S.C.W.; Liew C.C.; Fung K.P.; Waye M.M.Y.; Lee C.Y.;
Gene 210:345-350(1998)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT MET-167;
The FHL2 LIM-domain protein is implicated in hematopoiesis and leukemogenesis.
Qian Z.; Mao L.; Fernald A.; Yu H.; Luo R.; Anastasi J.; Le Beau M.M.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANT MET-167;
Slim defines a novel family of LIM-proteins expressed in skeletal muscle.
Morgan M.J.; Madgwick A.J.A.;
Biochem. Biophys. Res. Commun. 225:632-638(1996)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 127-279 (ISOFORM 1); VARIANT MET-167;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.