Variant position: 254 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 361 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TKASRKRLTVSLAYSESHQI RVSQQDFRLFRTLFLLMVSFF
Mouse TKASRKRLTLSLAYSESHQI RVSQQDYRLFRTLFLLMVSFF
Rat TKASRKRLTLSLAYSESHQI RVSQQDYRLFRTLFLLMVSFF
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 361 Free fatty acid receptor 4
226 – 268 Cytoplasmic
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human.
Ichimura A.; Hirasawa A.; Poulain-Godefroy O.; Bonnefond A.; Hara T.; Yengo L.; Kimura I.; Leloire A.; Liu N.; Iida K.; Choquet H.; Besnard P.; Lecoeur C.; Vivequin S.; Ayukawa K.; Takeuchi M.; Ozawa K.; Tauber M.; Maffeis C.; Morandi A.; Buzzetti R.; Elliott P.; Pouta A.; Jarvelin M.R.; Korner A.; Kiess W.; Pigeyre M.; Caiazzo R.; Van Hul W.; Van Gaal L.; Horber F.; Balkau B.; Levy-Marchal C.; Rouskas K.; Kouvatsi A.; Hebebrand J.; Hinney A.; Scherag A.; Pattou F.; Meyre D.; Koshimizu T.A.; Wolowczuk I.; Tsujimoto G.; Froguel P.;
Cited for: INVOLVEMENT IN BMIQ10; VARIANTS CYS-67 AND HIS-254; ASSOCIATION OF VARIANT HIS-254 WITH RISK OF OBESITY; FUNCTION;
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