Variant position: 156 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 459 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human QLQLHVGYFVLGRILCALLG DFGGLLAASFASVADVSSSRS
Mouse QLELHVGFFVLGRALCALLG DFNGLLAASFASVADVSSNHS
Rat QLQLHIGFFVLGRALCALLG DFNGLLAASFASVADVSSNHS
Bovine QLHLHIGYLVLGRILCALLG DFSGLLAASFASVADVSSSRT
Xenopus laevis YQELHVGYFLIGRFISGISG DFNMILAGCFAYIADVSDRQS
Zebrafish YLKLPVFWFLIGRICSGLSG DFNAILAGCFAYVADTSERGS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 459 Proton-coupled folate transporter
146 – 168 Helical
156 – 156 D -> E. Does not affect methotrexate uptake.
156 – 156 D -> FKNVW. Loss of methotrexate uptake.
156 – 156 D -> G. 2-fold reduction of methotrexate uptake.
156 – 156 D -> S. 8-fold reduction of methotrexate uptake.
Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption.
Shin D.S.; Min S.H.; Russell L.; Zhao R.; Fiser A.; Goldman I.D.;
Cited for: VARIANT HFM TYR-156; CHARACTERIZATION OF VARIANT HFM TYR-156; MUTAGENESIS OF ASP-109 AND ASP-156;
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