Variant position: 476 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 636 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VTQNELLKQQVKIFEEDFQR ERSDRERMNEEKEELKKQVEK
Mouse VTQNELLKQQVKIFEEDFQR ERSDRERMNEEKEELKKQVEK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 636 TNFAIP3-interacting protein 1
431 – 588 Required for inhibitory activity of TNF-induced NF-kappa-B activation
452 – 510 Ubiquitin-binding domain (UBD)
294 – 535
472 – 472 D -> N. Abolishes binding to polyubiquitin ('K-63'-linked and linear).
A20, ABIN-1/2, and CARD11 mutations and their prognostic value in gastrointestinal diffuse large B-cell lymphoma.
Dong G.; Chanudet E.; Zeng N.; Appert A.; Chen Y.W.; Au W.Y.; Hamoudi R.A.; Watkins A.J.; Ye H.; Liu H.; Gao Z.; Chuang S.S.; Srivastava G.; Du M.Q.;
Clin. Cancer Res. 17:1440-1451(2011)
Cited for: VARIANTS TRP-263; MET-286; THR-374 AND LYS-476;
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