Variant position: 668 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1117 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SLKNKTGTTQQHSQQFHIQS GAGSNIISVSTCAVNSADTKK
Mouse PVRNRAGMAPRWLQRCHTNS GT-YNLTSIPECPVHSAAGKK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1117 Centrosomal protein of 126 kDa
Exome sequencing identifies KIAA1377 and C5orf42 as susceptibility genes for monomelic amyotrophy.
Lim Y.M.; Koh I.; Park Y.M.; Kim J.J.; Kim D.S.; Kim H.J.; Baik K.H.; Choi H.Y.; Yang G.S.; Also-Rallo E.; Tizzano E.F.; Gamez J.; Park K.; Yoo H.W.; Lee J.K.; Kim K.K.;
Neuromuscul. Disord. 22:394-400(2012)
Cited for: VARIANT SER-668;
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