Variant position: 361 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 396 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VFQSNFQELYSGSRDCNILA WVPSLYEPVPDDD-ETTTKSQL
Mouse VFQPNFQELYSGSRDCNILA WVPPSYEPVPDDDDEAPAKSQ
Bovine VFQSNFQELYSGSRDCNILA WVPSLCESVPDDDDETSTRSQ
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 396 DNA excision repair protein ERCC-8
325 – 363 WD 7
206 – 396 Missing. In isoform 2.
358 – 363
A UV-sensitive syndrome patient with a specific CSA mutation reveals separable roles for CSA in response to UV and oxidative DNA damage.
Nardo T.; Oneda R.; Spivak G.; Vaz B.; Mortier L.; Thomas P.; Orioli D.; Laugel V.; Stary A.; Hanawalt P.C.; Sarasin A.; Stefanini M.;
Proc. Natl. Acad. Sci. U.S.A. 106:6209-6214(2009)
Cited for: VARIANT UVSS2 CYS-361;
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