Variant position: 235 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 300 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PFVPENNPERNHWHYRDLEA MARITGAEPIFIDANFQ-STVP
Mouse PFVPENSPERNHWYYRDLEA MAKITGADPIFIDADFH-STA
Rat PFVPENNPERSLWYYRDLDA MAKRTGTDPIFIDADFN-STT
Chicken PFVPENNIEKNRWHYRDLEA MAKVTGAEPIFIDADFR-STV
Xenopus tropicalis PFVPHNDPSRNLWHYKDLSA MAQVVGAEPILIDADRG-STV
Caenorhabditis elegans QFVGQNVPEQGVWYYRDLNQ MAKHYGTEPVLLDAAYE-TTV
Drosophila QFTPDH--KGNVYLYRDLAR MCAATGAAPVFLDAVYDPQTA
Slime mold AFTPTNQPEKGQWYSLDVDA MADQLNTEPLMINTMDE-TEI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 300 Surfeit locus protein 1
SURF1 gene mutations in Polish patients with COX-deficient Leigh syndrome.
Piekutowska-Abramczuk D.; Popowska E.; Pronicka E.; Karczmarewicz E.; Pronicki M.; Kmiec T.; Krajewska-Walasek M.;
J. Appl. Genet. 42:103-108(2001)
Cited for: VARIANT LS THR-235;
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