Variant position: 532 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 622 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TANVGKGQPSVLQVVNLPIV ERPVCKDSTRIRITDNMFCAG
Mouse TTNINEIQPSVLQVVNLPIV ERPVCKASTRIRITDNMFCAG
Rat TTNINEIQPSVLQVVNLPIV ERPVCKASTRIRITDNMFCAG
Pig TTSASEVQPSVLQVVNLPIV ERLVCKASTRIRITDNMFCAG
Bovine TTSVAEVQPSVLQVVNLPLV ERPVCKASTRIRITDNMFCAG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Primary structure of human prethrombin 2 and alpha-thrombin.
Butkowski R.J.; Elion J.; Downing M.R.; Mann K.G.;
J. Biol. Chem. 252:4942-4957(1977)
Cited for: PROTEIN SEQUENCE OF 315-622; GLYCOSYLATION AT ASN-416; VARIANT GLN-532;
Quantitative detection of single amino acid polymorphisms by targeted proteomics.
Su Z.D.; Sun L.; Yu D.X.; Li R.X.; Li H.X.; Yu Z.J.; Sheng Q.H.; Lin X.; Zeng R.; Wu J.R.;
J. Mol. Cell Biol. 3:309-315(2011)
Cited for: VARIANTS MET-165; LYS-200; THR-386 AND GLN-532; IDENTIFICATION BY MASS SPECTROMETRY;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.