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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P16519: Variant p.Lys484Glu

Neuroendocrine convertase 2
Gene: PCSK2
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Variant information Variant position: help 484
Type of variant: help LB/B
Residue change: help From Lysine (K) to Glutamate (E) at position 484 (K484E, p.Lys484Glu).
Physico-chemical properties: help Change from large size and basic (K) to medium size and acidic (E)
BLOSUM score: help 1
Other resources: help


Sequence information Variant position: help 484
Protein sequence length: help 638
Location on the sequence: help ERFHCVGGSVQDPEKIPSTG K LVLTLTTDACEGKENFVRYL
Residue conservation: help 
Human                         ERFHCVGGSVQDPEKIPSTGKLVLTLTTDACEGKENFVRYL

Mouse                         ERFHCVGGSVQNPEKIPPTGKLVLTLKTNACEGKENFVRYL

Rat                           ERFHCVGGSVQNPEKIPPTGKLVLTLQTNACEGKENFVRYL

Pig                           ERFHCVGGSVQDPEKIPSTGKLVLTLTTDACEGKENFVRYL

Bovine                        ERFHCVGGSVQNPEKIPTTGKPVLTLTTDACEGKENFVRYL

Caenorhabditis elegans        PRYHCTAGLIDTPHEIPADGNLILEINTDGCAGSQFEVRYL

Drosophila                    PRYHCEAGELTQPQAIVMGRSLFWEIKTDACKGTDTEVNYL
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 110 – 638 Neuroendocrine convertase 2
Domain 461 – 597 P/Homo B
Disulfide bond 468 – 494



Literature citations
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3); VARIANTS GLN-244 AND GLU-484;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.