Variant position: 186 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 712 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PPSSALPSGTRSLPRPIDGV SDWSQGCSLRSTGSPASLASN
Mouse QPPSASPAVTRSQPRPID-T PDWSWGHTLHSTNSTASLASH
Bovine PPSSASLSRTRSDPRPIEHL SGWSTACSLRSTGSPASLGSN
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 712 TIR domain-containing adapter molecule 1
190 – 190 (Microbial infection) Cleavage; by viral HAV 3CD
190 – 190 Q -> A. No effect on cleavage by Seneca Valley virus protease 3C.
190 – 190 Q -> R. No cleavage by HAV 3CD.
202 – 202 S -> A. Decreased interaction with IRF3.
Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency.
Sancho-Shimizu V.; Perez de Diego R.; Lorenzo L.; Halwani R.; Alangari A.; Israelsson E.; Fabrega S.; Cardon A.; Maluenda J.; Tatematsu M.; Mahvelati F.; Herman M.; Ciancanelli M.; Guo Y.; AlSum Z.; Alkhamis N.; Al-Makadma A.S.; Ghadiri A.; Boucherit S.; Plancoulaine S.; Picard C.; Rozenberg F.; Tardieu M.; Lebon P.; Jouanguy E.; Rezaei N.; Seya T.; Matsumoto M.; Chaussabel D.; Puel A.; Zhang S.Y.; Abel L.; Al-Muhsen S.; Casanova J.L.;
J. Clin. Invest. 121:4889-4902(2011)
Cited for: VARIANT IIAE6 LEU-186;
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