Variant position: 417 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 483 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GEESRLESGMQNMSIHTKTT SG----YAG-----------GLSSAYGGLTSPGLSY
Mouse GEESRLESGMQNMSIHTKTT SG----YSG-----------G
Rat GEESRLESGMQNMSIHTKTT SG----YAG-----------G
Bovine GEESRLESGMQNMSIHTKTT SG----YAG-----------G
Xenopus laevis GEESRLESGFQNLSIQTKTV SGVSSGFGG-----------G
Zebrafish GEEDRLATGIKAINISKQST S-----YGGYPMESAGSSYST
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 483 Keratin, type II cytoskeletal 8
399 – 483 Tail
400 – 400 Phosphoserine
404 – 404 Phosphoserine
410 – 410 Phosphoserine
417 – 417 Phosphoserine
424 – 424 Phosphoserine
432 – 432 Phosphoserine; by CaMK2 and MAPK
Organization and sequence of the human gene encoding cytokeratin 8.
Krauss S.; Franke W.W.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT GLY-417;
Cytokeratin expression in simple epithelia. III. Detection of mRNAs encoding human cytokeratins nos. 8 and 18 in normal and tumor cells by hybridization with cDNA sequences in vitro and in situ.
Leube R.E.; Bosch F.X.; Romano V.; Zimbelmann R.; Hofler H.; Franke W.W.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 205-483 (ISOFORM 1); VARIANTS GLY-417 AND ASP-429;
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