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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P47871: Variant p.Pro86Ser

Glucagon receptor
Gene: GCGR
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Variant information Variant position: help 86 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Proline (P) to Serine (S) at position 86 (P86S, p.Pro86Ser). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from medium size and hydrophobic (P) to small size and polar (S) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help In MVAH; abolishes glucagon binding. Any additional useful information about the variant.


Sequence information Variant position: help 86 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 477 The length of the canonical sequence.
Location on the sequence: help SCWPDTPANTTANISCPWYL P WHHKVQHRFVFKRCGPDGQW The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         SCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQW

Mouse                         SCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQW

Rat                           SCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQW

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 26 – 477 Glucagon receptor
Topological domain 26 – 136 Extracellular
Glycosylation 74 – 74 N-linked (GlcNAc...) asparagine
Glycosylation 78 – 78 N-linked (GlcNAc...) asparagine
Disulfide bond 58 – 100
Disulfide bond 81 – 121
Turn 86 – 90



Literature citations
Structure of the human glucagon class B G-protein-coupled receptor.
Siu F.Y.; He M.; de Graaf C.; Han G.W.; Yang D.; Zhang Z.; Zhou C.; Xu Q.; Wacker D.; Joseph J.S.; Liu W.; Lau J.; Cherezov V.; Katritch V.; Wang M.W.; Stevens R.C.;
Nature 499:444-449(2013)
Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 123-432; FUNCTION; SUBCELLULAR LOCATION; DISULFIDE BONDS; MEMBRANE TOPOLOGY; MUTAGENESIS OF TRP-36; ASP-63; ALA-135; TYR-145; TYR-149; LEU-198; ARG-201; TYR-202; ASP-208; TRP-215; GLN-232; TYR-233; LYS-286; GLU-290; CYS-294; TRP-295; TRP-304; LEU-382 AND LEU-386; CHARACTERIZATION OF VARIANT MVAH SER-86; Homozygous P86S mutation of the human glucagon receptor is associated with hyperglucagonemia, alpha cell hyperplasia, and islet cell tumor.
Zhou C.; Dhall D.; Nissen N.N.; Chen C.R.; Yu R.;
Pancreas 38:941-946(2009)
Cited for: VARIANT MVAH SER-86; INVOLVEMENT IN MVAH; FUNCTION; SUBCELLULAR LOCATION; CHARACTERIZATION OF VARIANT MVAH SER-86;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.